Day: October 27, 2022

A key application of digital medical tools is in diagnostic applications that rely on artificial intelligence (AI) algorithms. Experts opine that there are critical deficiencies in the methods used for training and validation of AI tools that might over-estimate the accuracy of these products, and hence make them less reliable. These deficiencies must be addressed … Read more

A new drug can affect multiple aspects of the disease it is intended to treat, and hence clinical trials are designed to evaluate multiple efficacy endpoints compared to the controls. However, evaluating multiple endpoints in a clinical trial should involve appropriate statistical adjustments to account for the existence of multiple comparisons, called the multiplicity effect. … Read more